February 6, 2026

If you notice any unusual symptoms, get medical help right away. These symptoms can be serious and might mean stopping the treatment. But, many find ways to handle these issues by changing their lifestyle or adjusting the dose. Low dose naltrexone can cause stomach issues like nausea and discomfort. It may also change how you feel about food and affect your digestion.

  • They may suggest over-the-counter pain relievers, such as ibuprofen (Advil, Motrin).
  • Also tell them if you smoke, drink alcohol, or use illegal drugs.
  • Its mechanism involving endorphins and opioid receptors can influence mood and may offer a new avenue in mental health treatment.
  • Possibly, but this wasn’t specifically reported in the drug’s studies.

When to Seek Medical Help

Additionally, customizing dosages allows patients to optimize its effects drug addiction treatment based on changing health needs and goals. According to Dr. Sajad Zalzala, or Dr. Z, Co-founder and Chief Medical Officer of AgelessRx, LDN is an excellent long-term medication due to its health benefits and potential for longevity. Many patients experience sustained improvements in healthspan and quality of life while on LDN, making it a favorable choice for ongoing use.

Personalized intensive therapy from home

If you experience persistent side effects, you must talk to your doctor. To learn more about naltrexone, you must bear with me for another 5-7 minutes. We will be discussing naltrexone, including what it is, what the advantages or disadvantages of naltrexone are, and potential indications and modes of action.

Fuel groundbreaking medical research!

long-term side effects of low-dose naltrexone

As research progresses, LDN may become a cornerstone in the management of chronic pain conditions, offering a new avenue for patients seeking relief from persistent pain and inflammation. For example, in multiple sclerosis trials, LDN reduced pain frequency and severity. However, more well-designed research is needed to confirm its efficacy and establish optimal dosing and treatment duration. As evidence grows, LDN may become a viable option for managing chronic pain conditions. This mechanism of action is particularly significant for individuals with autoimmune diseases such as rheumatoid arthritis and multiple sclerosis. The increased production of endogenous opioids helps modulate the immune system, reducing inflammation—a key factor in these conditions.

long-term side effects of low-dose naltrexone

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Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of naltrexone injection in the elderly. Our pharmacists are experienced and will help counsel patients new to taking LDN. Overall, LDN is well-tolerated by most patients, with side effects often subsiding after the initial weeks of treatment. Some patients have reported experiencing mental changes and mood swings, including increased irritability. Some ingredients may interact with this medication and cause side effects.

However, there was a significant decrease in the timed walk in patients in the LDN–Copaxone naltrexone side effects cohort when analyzing baseline and final measurements (6.3 and 5.1 seconds, respectively). No differences were noted in baseline to final measurements in the LDN-only group (6.2 and 5.9 seconds, respectively). The actual price you’ll pay depends on your insurance plan, your location, and the pharmacy you use. The following information describes dosages that are commonly prescribed or recommended. However, be sure to take the dosage your doctor prescribes for you.

Blood tests may be conducted to monitor liver function and other vital parameters. Most doctors recommend regular follow-ups to manage dosage adjustment and side effect management. Always consult a doctor  or pharmacist for personalized naltrexone dosage.

Medications & Supplements

Because of these effects, LDN is used to support overall health, improve quality of life, and help manage chronic conditions, all without suppressing the immune system. Patients participating in the study reported reduced fatigue, improved emotional health, decreased pain, and boosted energy levels. These results show that LDN can enhance multiple aspects of daily life, with significant increases in quality of life over time.

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